Just in case you dont want other people using hot keys in your computer i.e. You dont want people to lock down or log off your computer using hot keys ( WIN + L ) and similar commands this utility comes in handy.
Basically it changes a key in computer’s registery to do this
HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Policies
The value is: NoWinKeys (DWORD Value)
Set to 1 = Hotkeys disabled. Set to 0 = Hotkeys enabled
But with this small utility now you can do this in one click. Download Disbale Windows Hot key
Related : How to prevent users from shutting down or restarting XP and VIsta